刘雪松, PhD副教授研究员博士生导师

电话：

邮箱： liuxs@@shanghaitech.edu.cn

传真： 86-21-20685430

地址：上海市浦东新区华夏中路393号

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中文信息English

肿瘤分子遗传学研究组

课题组长

姓名：

刘雪松副教授研究员博士生导师, PhD, 副教授

职务：

所在院所：

新葡萄3522登录网页版

荣誉称号：

教育经历：

1998/09—2002/07，武汉大学，学士
2002/09—2007/07，中国科学院上海生命科学研究院健康科学研究所，博士

博士后及工作经历：

2008/10—2015/05，美国哈佛大学，博士后
2015/06—2022/09，我校，新葡萄3522登录网页版，助理教授（TENURE-TRACK）
2022/09—至今，我校，新葡萄3522登录网页版，副教授（TENURED）

课题组简介

研究方向：

肿瘤分子遗传与免疫基因组学

研究内容：

恶性肿瘤本质上是由体细胞DNA变异诱发的系统疾病，本实验室方向是从基因组DNA变异角度系统研究肿瘤发生以及演化的规律，寻找预测肿瘤临床表现的标志物，并设计针对性的治疗策略。目前实验室的具体研究内容包括：1，从肿瘤基因组角度探讨免疫治疗临床实践中遇到的关键科学问题。如，开发新的肿瘤基因组标志物以高效区分免疫治疗有反应和不反应病人；研究肿瘤细胞免疫原性的分子遗传基础，进而设计提高肿瘤细胞免疫原性的新策略，从而把免疫治疗不反应病人变成有反应病人。2，研究肿瘤基因组DNA复杂变异的特征模式，背后驱动因素以及临床相关性。重点关注拷贝数变异（copy number alteration）、插入删除（small indel）的变异模式，与肿瘤临床尤其是免疫治疗的内在关系。3，利用生化细胞、小鼠模型研究肿瘤新靶标和机制，尤其关注新的肿瘤代谢靶点、新的非编码变异的功能与机制。实验室应用到的技术手段包括：肿瘤基因组生物信息学分析、生化细胞技术和小鼠模型。

课题组网站：

http://liuxslab.slst.shanghaitech.edu.cn/

研究成果展示

刘雪松课题组的科研工作围绕肿瘤精准诊断和治疗的实际临床需求，抓住肿瘤发生发展的根本驱动因素DNA变异，从基因组DNA变异大数据分析角度寻找肿瘤精准诊断标志物以及治疗靶点。首次报道特征性的基因组DNA变异模式（APOBEC变异模式）能作为肺癌免疫治疗效果预测的标志物；创新性地定量了肿瘤的免疫原性，并据此开发出一种比目前已知的免疫治疗标志物精确度和实用性均更为优异的标志物（肿瘤免疫原性指数，TIGS）；首次发现肿瘤免疫治疗标志物TMB的临床预测效果的性别差异；开发了新的肿瘤新抗原免疫原性识别工具；首次实现肿瘤新抗原介导免疫编辑信号的系统定量；开发了一系列肿瘤基因组分析工具Sigflow, Sigminer, UCSCXenaTools, UCSCXenaShiny等；发现了新的肿瘤驱动因素与治疗靶点如GGCT，FLAD1等；上述研究成果大大扩展了对肿瘤精准诊断和治疗基因组学标志物、肿瘤新抗原疫苗开发、肿瘤新治疗靶点的认识，具有重要的实际应用场景，受到学术界的广泛关注与引用，据此也申报多项发明专利。刘雪松连续入选Elsevier发布的2021年度、2022年度“中国高被引学者”榜单。

代表性论文（*第一作者，#通讯作者）

1. Ning, Wei*; Wu, Tao; Wu, Chenxu; Wang, Shixiang; Tao, Ziyu; Wang, Guangshuai; Zhao, Xiangyu; Diao, Kaixuan; Wang, Jinyu; Chen, Jing; Chen, Fuxiang; Liu, Xue-Song^#.Accurate prediction of pan-cancer types using machine learning with minimal number of DNA methylation sites.JOURNAL OF MOLECULAR CELL BIOLOGY. Apr 2023.
2. Wang, Guangshuai*; Wu, Tao; Ning, Wei; Diao, Kaixuan; Sun, Xiaoqin; Wang, Jinyu; Wu, Chenxu; Chen, Jing; Xu, Dongliang; Liu, Xue-Song^#.TLimmuno2: predicting MHC class II antigen immunogenicity through transfer learning.BRIEFINGS IN BIOINFORMATICS. Mar 2023.
3. Tao, Ziyu*; Wang, Shixiang; Wu, Chenxu; Wu, Tao; Zhao, Xiangyu; Ning, Wei; Wang, Guangshuai; Wang, Jinyu; Chen, Jing; Diao, Kaixuan; Chen, Fuxiang; Liu, Xue-Song^#.The repertoire of copy number alteration signatures in human cancer.BRIEFINGS IN BIOINFORMATICS. 01 Feb 2023.
4. Wu, Tao*; Diao, Kaixuan; Liu, Xue-Song^#.Quantification of Neoantigen-Mediated Immunoediting in Cancer Evolution-Reply.CANCER RESEARCH. Mar 2023. 83(6):973.
5. Diao, Kaixuan*; Chen, Jing; Wu, Tao; Wang, Xuan; Wang, Guangshuai; Sun, Xiaoqin; Zhao, Xiangyu; Wu, Chenxu; Wang, Jinyu; Yao, Huizi; Gerarduzzi, Casimiro; Liu, Xue-Song^#.Seq2Neo: A Comprehensive Pipeline for Cancer Neoantigen Immunogenicity Prediction.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Oct 2022. 23(19).
6. Zhao, Xiangyu*; Chen, Yuxing; Sun, Xiaoqin; He, Zaoke; Wu, Tao; Wu, Chenxu; Chen, Jing; Wang, Jinyu; Diao, Kaixuan; Liu, Xue-Song^#.Oncogenic EFNA4 Amplification Promotes Lung Adenocarcinoma Lymph Node Metastasis.CANCERS. Sep 2022. 14(17).
7. Jianfeng Li^#*; Benben Miao*; Shixiang Wang*; Wei Dong*; Houshi Xu*; Chenchen Si*; Wei Wang; Songqi Duan; Jiacheng Lou; Zhiwei Bao; Hailuan Zeng; Zengzeng Yang; Wenyan Cheng; Fei Zhao; Jianming Zeng; Xue-Song Liu^#; Renxie Wu^#; Yang Shen^#; Zhu Chen^#; Saijuan Chen^#; Mingjie Wang^#.Hiplot: a comprehensive and easy-to-use web service for boosting publication-ready biomedical data visualization.BRIEFINGS IN BIOINFORMATICS. Jul 2022.
8. Wu, Tao*; Wang, Guangshuai; Wang, Xuan; Wang, Shixiang; Zhao, Xiangyu; Wu, Chenxu; Ning, Wei; Tao, Ziyu; Chen, Fuxiang; Liu, Xue-Song^#.Quantification of neoantigen-mediated immunoediting in cancer evolution.CANCER RESEARCH. 15 Jun 2022. 82(12).
9. Wu, Tao*; Wu, Chenxu*; Zhao, Xiangyu; Wang, Guangshuai; Ning, Wei; Tao, Ziyu; Chen, Fuxiang; Liu, Xue-Song^#.Extrachromosomal DNA formation enables tumor immune escape potentially through regulating antigen presentation gene expression.SCIENTIFIC REPORTS. Mar 2022.
10. He, Zaoke*; Sun, Xiaoqin; Wang, Shixiang; Bai, Dongsheng; Zhao, Xiangyu; Han, Ying; Hao, Piliang; Liu, Xue-Song^#.Ggct (g-glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival.BRITISH JOURNAL OF HAEMATOLOGY. Oct 2021. 195(2):267-275.
11. Wang, Shixiang*; Xiong, Yi; Zhao, Longfei; Gu, Kai; Li, Yin; Zhao, Fei; Li, Jianfeng; Wang, Mingjie; Wang, Haitao; Tao, Ziyu; Wu, Tao; Zheng, Yichao; Li, Xuejun^#; Liu, Xue-Song^#.UCSCXenaShiny: An R/CRAN Package for Interactive Analysis of UCSC Xena Data.BIOINFORMATICS. Jul 2021. 38(2).
12. Wang, Shixiang*; Li, Huimin; Song, Minfang; Tao, Ziyu; Wu, Tao; He, Zaoke; Zhao, Xiangyu; Wu, Kai; Liu, Xue-Song^#.Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes.PLOS GENETICS. May 2021.
13. He, Zaoke*; Wu, Tao; Wang, Shixiang; Zhang, Jing; Sun, Xiaoqin; Tao, Ziyu; Zhao, Xiangyu; Li, Huimin; Wu, Kai; Liu, Xue-Song^#.Pan-cancer noncoding genomic analysis identifies functional CDC20 promoter mutation hotspots.ISCIENCE. Mar 2021.
14. Wang, Shixiang*; Tao, Ziyu; Wu, Tao; Liu, Xue-Song^#.Sigflow: an automated and comprehensive pipeline for cancer genome mutational signature analysis.BIOINFORMATICS. 01 Jun 2021.
15. Wang, Shixiang*; He, Zaoke; Wang, Xuan; Li, Huimin; Liu, Xue-Song^#.Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction.ELIFE. 26 Nov 2019. 8.
16. Wang, Shixiang*; Jia, Mingming*; He, Zaoke; Liu, Xue-Song^#.APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer.ONCOGENE. 19 Jul 2018. 37(29):3924-3936.
17. Wang, Shixiang*; Zhang, Jing; He, Zaoke; Wu, Kai; Liu, Xue-Song^#.The predictive power of tumor mutational burden in lung cancer immunotherapy response is influenced by patients' sex.INTERNATIONAL JOURNAL OF CANCER. 15 Nov 2019. 145(10):2840-2849.
18. He, Zaoke*; Wang, Shixiang; Shao, Yuanyuan; Zhang, Jing; Wu, Xiaolin; Chen, Yuxing; Hu, Junhao; Zhang, Feng; Liu, Xue-Song^#.Ras Downstream Effector GGCT Alleviates Oncogenic Stress.ISCIENCE. 27 Sep 2019. 19:256-266.
19. Wang, Shixiang*; Cowley, Li An*; Liu, Xue-Song^#.Sex Differences in Cancer Immunotherapy Efficacy, Biomarkers, and Therapeutic Strategy.MOLECULES. Sep 2019. 24(18).
20. Shixiang Wang*; Xuesong Liu^#.The UCSCXenaTools R package: a toolkit for accessing genomics data from UCSC Xena platform, from cancer multi-omics to single-cell RNA-seq.JOURNAL OF OPEN SOURCE SOFTWARE. 05 Aug 2019. 4(40).
21. Wang, Shixiang*; He, Zaoke; Wang, Xuan; Li, Huimin; Wu, Tao; Sun, Xiaoqin; Wu, Kai; Liu, Xue-Song^#.Can tumor mutational burden determine the most effective treatment for lung cancer patients?.LUNG CANCER MANAGEMENT. Dec 2019. 8(4).
22. Chen, Ming*; Zhang, Jiangwen; Sampieri, Katia; Clohessy, John G.; Mendez, Lourdes; Gonzalez-Billalabeitia, Enrique; Liu, Xue-Song; Lee, Yu-Ru; Fung, Jacqueline; Katon, Jesse M.; Menon, Archita Venugopal; Webster, Kaitlyn A.; Ng, Christopher; Palumbieri, Maria Dilia; Diolombi, Moussa S.; Breitkopf, Susanne B.; Teruya-Feldstein, Julie; Signoretti, Sabina; Bronson, Roderick T.; Asara, John M.; Castillo-Martin, Mireia; Cordon-Cardo, Carlos; Pandolfi, Pier Paolo^#.An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.NATURE GENETICS. 2018. 50(2):206+.
23. Gerarduzzi, Casimiro*; de Polo, Anna; Liu, Xue-Song; El Kharbili, Manale; Little, John B.; Yuan, Zhi-Min^#.Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.JOURNAL OF BIOLOGICAL CHEMISTRY. 2016. 291(50):25937-25949.
24. Liu, X-S*; Liu, Z.; Gerarduzzi, C.; Choi, D. E.; Ganapathy, S.; Pandolfi, P. P.; Yuan, Z-M^#.Somatic human ZBTB7A zinc finger mutations promote cancer progression.ONCOGENE. 09 Jun 2016. 35(23):3071-3078.
25. Liu, Xue-Song*; Chandramouly, Gurushankar; Rass, Emilie; Guan, Yinghua; Wang, Guocan; Hobbs, Robin M.; Rajendran, Anbazhagan; Xie, Anyong; Shah, Jagesh V.; Davis, Anthony J.; Scully, Ralph^#; Lunardi, Andrea^#*; Pandolfi, Pier Paolo^#.LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.NATURE COMMUNICATIONS. 2015. 6.
26. Liu, Xue-Song*; Genet, Matthew D.; Haines, Jenna E.; Mehanna, Elie K.; Wu, Shaowei; Chen, Hung-I Harry; Chen, Yidong; Qureshi, Abrar A.; Han, Jiali; Chen, Xiang; Fisher, David E.; Pandolfi, Pier Paolo; Yuan, Zhi-Min^#.ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.MOLECULAR CANCER RESEARCH. 2015. 13(8):1206-1217.
27. Liu, Xue-Song*; Little, John B.; Yuan, Zhi-Min^#.Glycolytic metabolism influences global chromatin structure.ONCOTARGET. 2015. 6(6):4214-4225.
28. Gonzalez-Billalabeitia, Enrique*; Seitzer, Nina; Song, Su Jung; Song, Min Sup; Patnaik, Akash; Liu, Xue-Song; Epping, Mirjam T.; Papa, Antonella; Hobbs, Robin M.; Chen, Ming; Lunardi, Andrea; Ng, Christopher; Webster, Kaitlyn A.; Signoretti, Sabina; Loda, Massimo; Asara, John M.; Nardella, Caterina; Clohessy, John G.; Cantley, Lewis C.; Pandolfi, Pier Paolo^#.Vulnerabilities of PTEN-TP53-Deficient Prostate Cancers to Compound PARP-PI3K Inhibition.CANCER DISCOVERY. 2014. 4(8):896-904.
29. Liu, Xue-Song*; Haines, Jenna E.; Mehanna, Elie K.; Genet, Matthew D.; Ben-Sahra, Issam; Asara, John M.; Manning, Brendan D.; Yuan, Zhi-Min^#.ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis.GENES & DEVELOPMENT. 2014. 28(17):1917-1928.
30. Wang, Guocan*; Lunardi, Andrea; Zhang, Jiangwen; Chen, Zhenbang; Ala, Ugo; Webster, Kaitlyn A.; Tay, Yvonne; Gonzalez-Billalabeitia, Enrique; Egia, Ainara; Shaffer, David R.; Carver, Brett; Liu, Xue-Song; Taulli, Riccardo; Kuo, Winston Patrick; Nardella, Caterina; Signoretti, Sabina; Cordon-Cardo, Carlos; Gerald, William L.; Pandolfi, Pier Paolo^#.Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion.NATURE GENETICS. 2013. 45(7):739+.
31. Zhang, Hong-Xin*; Liu, Zi-Xing; Sun, Yue-Ping; Zhu, Jiang; Lu, Shun-Yuan; Liu, Xue-Song; Huang, Qiu-Hua; Xie, Yin-Yin; Zhu, Hou-Bao; Dang, Su-Ying; Chen, Hai-Feng; Zheng, Guang-Yong; Li, Yi-Xue; Kuang, Ying; Fei, Jian; Chen, Sai-Juan; Chen, Zhu^#; Wang, Zhu-Gang^#.Rig-I regulates NF-kappa B activity through binding to Nf-kappa b1 3 '-UTR mRNA.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013. 110(16):6459-6464.
32. Xue-Song Liu*; Xu-Dong Zhao*; Xiaoxing Wang*; Yi-Xin Yao; Liang-Liang Zhang; Run-Zhe Shu; Wei-Hua Ren; Ying Huang; Lei Huang; Ming-Min Gu; Ying Kuang; Long Wang; Shun-Yuan Lu; Jun Chi; Jing-Sheng Fen; Yi-Fei Wang; Jian Fei; Wei Dai^#; Zhu-Gang Wang^#.Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E.GENES CANCER. Jan 2010. 1(1):26-39.
33. Shu, Run-Zhe^#*; Zhang, Feng; Liu, Xue-Song; Li, Chun-Liang; Wang, Long; Tai, Yi-Lin; Wu, Xiao-Lin; Yang, Xue; Liao, Xiao-Dong; Jin, Ying; Gu, Ming-Min; Huang, Lei; Pang, Xiao-Fen^#; Wang, Zhu-Gang^#.Target Deletion of the Cytoskeleton-Associated Protein Palladin Does Not Impair Neurite Outgrowth in Mice.PLOS ONE. 2009. 4(9).
34. Wu, Xiao-lin*; Gu, Ming-min; Huang, Lei; Liu, Xue-song; Zhang, Hong-xin; Ding, Xiao-yi; Xu, Jian-qing; Cui, Bin; Wang, Long; Lu, Shun-yuan; Chen, Xiao-yi; Zhang, Hai-guo; Huang, Wei; Yuan, Wen-tao; Yang, Jiang-ming; Gu, Qun; Fei, Jian; Chen, Zhu; Yuan, Zhi-min; Wang, Zhu-gang^#.Multiple Synostoses Syndrome Is Due to a Missense Mutation in Exon 2 of FGF9 Gene.AMERICAN JOURNAL OF HUMAN GENETICS. 2009. 85(1):53-63.
35. Wang, Yi*; Zhang, Hong-Xin; Sun, Yue-Ping; Liu, Zi-Xing; Liu, Xue-Song; Wang, Long; Lu, Shun-Yuan; Kong, Hui; Liu, Qiao-Ling; Li, Xi-Hua; Lu, Zhen-Yu; Chen, Sai-Juan; Chen, Zhu; Bao, Shi-San; Dai, Wei; Wang, Zhu-Gang^#.Rig-I-/- mice develop colitis associated with downregulation of G alpha i2.CELL RESEARCH. 2007. 17(10):858-868.
36. Liu, Xue-Song*; Luo, Hui-Jun; Yang, Hua; Wang, Long; Kong, Hui; Jin, Yue-E; Wang, Fang; Gu, Ming-Min; Chen, Zhu; Lu, Zhen-Yu; Wang, Zhu-Gang^#.Palladin regulates cell and extracellular matrix interaction through maintaining normal actin cytoskeleton architecture and stabilizing beta1-integrin.JOURNAL OF CELLULAR BIOCHEMISTRY. 2007. 100(5):1288-1300.
37. Liu, Xue-Song*; Li, Xi-Hua; Wang, Yi; Shu, Run-Zhe; Wang, Long; Lu, Shun-Yuan; Kong, Hui; Jin, Yue-E; Zhang, Li-Jun; Fei, Jian; Chen, Sai-Juan; Chen, Zhu; Gu, Ming-Min; Lu, Zhen-Yu; Wang, Zhu-Gang^#.Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver.BLOOD. 2007. 110(3):870-876.
38. Luo, HJ*; Liu, XS*; Wang, F; Huang, QH; Shen, SH; Wang, L; Xu, GJ; Sun, X; Kong, H; Gu, MM; Chen, SJ; Chen, Z; Wang, ZG^#.Disruption of palladin results in neural tube closure defects in mice.MOLECULAR AND CELLULAR NEUROSCIENCE. 2005. 29(4):507-515.

专著

专利

1. 刘雪松; 王诗翔，一种肿瘤免疫生物标志物及其用途，中国，CN201711110798，发明专利
2. 刘雪松; 王诗翔; 何早柯，一种肿瘤免疫治疗的标志物，中国，201811376543.8，发明专利
3. 刘雪松; 王诗翔; 何早柯; 王轩; 李慧敏; 陈玉星，一种简易高效的肿瘤免疫治疗生物标志物及其用途，中国，201910501626.3，发明专利
4. 刘雪松; 王诗翔，一种肿瘤基因组拷贝数变异特征模式识别方法及其应用，中国，CN202011516653.7，发明专利
5. 刘雪松; 陶紫玉; 吴宸旭，一种简洁全面的拷贝数变异模式识别方法及其应用，中国，CN202110834969.9，发明专利
6. 刘雪松; 吴涛，一种肿瘤样本免疫编辑状态定量方法及其应用，中国，202111532372.5，发明专利
7. 刘雪松; 王轩; 吴涛，一种肿瘤新抗原特征分析与免疫原性预测工具及其应用，中国，202210117578.X，发明专利
8. 刘雪松; 赵翔宇，一类适应低氧或缺氧微环境的肿瘤的治疗靶点及其应用，中国，202210004820.2，发明专利

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姓名：孙晓琴

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